aaiey ainoiaa?ii ia eciaiyeenu (enoiaii 67,9±15,3 ea, a eiioa
enneaaiaaiey 66,0±16,0 ea). Eciaiaiey AA e ?NN auee iacia?e-
oaeuiuie e iaainoiaa?iuie.
Onoaiiaeaii, ?oi ioaiee iauae aeoeaiinoe aieuiuo ii oeaea
Ea?iianeiai e eiioo oa?aiee OON o 16 ec 28 aieuiuo iiauneeenu
ia 10-30%, o 6 ia eciaieeenu e o 6 nieceeenu ia 10-20% a nayce
n oooaoaieai ninoiyiey ia oiia i?ia?anne?iaaiey caaieaaa-
iey. Aeiaieea iauaai ninoiyiey ioaiaia eae «aac eciaiaiee»
o 7 iaoeaioia, «iacia?eoaeuiia oooaoaiea» — o 13, «cia?eoaeu-
iia oooaoaiea» — o 7, «oeo?oaiea» — o 1 iaoeaioa.
2 iaoeaioee oia?ee (iaia ia 18-a, a?oaay — ia 20-a nooee ii-
nea aee??aiey a enneaaiaaiea) io i?e?ei ia naycaiiuo n oa?a-
ieae a??iaaceeii. A iaiii neo?aa nia?ou ianooieea io i?enia-
aeiaiey oeaaiiiu oaca ia oiia ?aniaaa?uaeny iiooiee i?y-
iie eeoee, a a?oaii iaoeaioea n ?ani?ino?aiaiiui
iiooieaaui i?ioannii e oy?aeui OAN. naycaiiui n ii?a?aie-
ai aieaa o?ao aieuoeo iaeanoae, oia?ea i?e yaeaieyo ia?anoa-
iey ?aeiaie eioieneeaoee ca iaaae? ai ieii?aiey enneaaiaa-
iey.
Iauaa aia?aoeaiea iaoeaioia io oa?aiee a??iaaceeii auei
i?aeiouanoaaiii ioee?iui (15 iaoeaioia) e oi?ioei (11 iaoe-
aioia). A aaoo ?anniio?aiiuo auoa neo?ayo — oaiaeaoai?e-
oaeuiui.
Oaianoai oa?aiee iiaaaey?uaa aieuoeinoai iaoeaioia (25
ec 28) ioaieee eae «ioee?iia» e 3 eae «oi?ioaa».
Aieuoeinoai iaoeaioia ioaaee i?aaii?oaiea a??iaaceeo ii
n?aaiaie? n i?aaoanoao?uae iieieaiie oa?aieae (?en. 4) a
nayce n eo?oei yooaeoii iaacaieeaaiey eee aieuoei oaiano-
aii oa?aiee.
Eaeea-eeai ianoiua ?aaeoee ei?e, naycaiiua n aiieeeaoeae
OON, ia iaae?aaeenu o iaoeaioia, aee??aiiuo a enneaaiaaiea.
Iano?aaiea ?acoeuoaoia.
Iieo?aiiua aeaaii?eyoiua ?a-
coeuoaou ea?aiey o?iie?aneie ?aeiaie aiee n iiiiuu? OON
«A??iaacee» niaeano?ony n ?acoeuoaoaie ca?oaa?iuo enneaai-
aaiee.
DC Vicinti Fatcia e niaao. [4] n?eoa?o yoio i?aia?ao yooaeoea-
iui e aaciianiui i?e aeeoaeuiie oa?aiee, a oii ?enea a neo?a-
yo, eiaaa a?oaea ia?eioe?aneea aiaeuaaoeee ia iaania?eaa?o
aaaeaaoiie aiaeaacee.
A enneaaiaaiee, auiieiaiiii o 53 iieieiae?aneeo aieuiuo,
?aiaa iieo?aaoeo ii?oei a n?aaiae aica 193 ia/noo, ?.E. Sloan
e niaao. [8] onoaiiaeee aunieo? yooaeoeaiinou, aaciianiinou e
oi?ioo? ia?aiineiinou OON oaioaieea a n?aaiae aica 167
iea/?, i?e?ai aieuoeinoai iaoeaioia ioaieaaee ea?anoai
aiaeaacee eo?oa, ?ai i?e i?a?iae oa?aiee ii?oeiii.
Ia oi?ioea aiaeuaaoe?aneea naienoaa e eiioi?oaaaeuiinou
oa?aiee OON-«A??iaacee» oeacuaa?o G.B. Georges e niaao. [5]
Ii iiaie? S.C. Lee e niaao. [7], oaioaiee o?ainaa?iaeuiue
aeaaiaa?y yooaeoeaiinoe e aaciianiinoe ii?ao i?eiaiyouny a
ea?anoaa aeuoa?iaoeau ii?oeio noeuoaoo i?aeuiiio.
A. Aaaaao e niaao. [2] a n?aaieoaeuiii enneaaiaaiee o 27 ia-
oeaioia iieo?eee aiaeiae?iua ?acoeuoaou io oa?aiee aiee OON
oaioaieea e oaaeaoeaie ii?oeia noeuoaoa iaaeaiiiai aunai-
ai?aaiey.
Iiai?iua yooaeou OON oaioaieea, ii aaiiui anao ia?a?en-
eaiiuo enneaaiaaoaeae, ia ioee?a?ony io oaeiauo, naienoaai-
iuo a?oaei iieieaai. Aeea?ae?aneea yaeaiey ia ei?a a ianoao
oeenaoee ieanou?y ?aaee.
Caee??aiea.
O?ainaa?iaeuiay oa?aiaaoe?aneay nenoaia
oaioaieea — «A??iaacee» yaeyaony aunieiyooaeoeaiui n?aa-
noaii ono?aiaiey o?iie?aneiai aieaaiai neia?iia, aucaaiiiai
iieieiae?aneei caaieaaaieai.
A??iaacee a aieuoeinoaa neo?aaa iaania?eaaao eo?oaa ea-
?anoai aiaeaacee, ?ai ?aiaa i?eiaiyaoeany iaoeaioaie neeu-
iua iieieaiua aiaeuaaoeee (ii?oei, iiiiiii, i?iiaaie, aoi-
?aii?oei). Iieiay aiaeaacey n iiiiuu? a??iaaceea (eae e
ii?oeia) ia ainoeaaaony oieuei a ioaaeuiuo neo?ayo iaeaieaa
oy?aeiai iae?iiaoe?aneiai aieaaiai neia?iia, ieioi iiaaa?-
uaainy ea?aie? aa?a ianneaiuie aicaie iieieaia.
Oaianoai oa?aiee (iaei?iay aiieeeaoey ieanou?y n oaioaie-
eii) o anao iaoeaioia iieo?aao ioaiee «ioee?ii» e «oi?ioi»
(i?aiaeaaaao ioaiea «ioee?ii»).
Iiai?iua yooaeou a??iaaceea a 2/3 neo?aaa iaiaa au?a?a-
iu ii n?aaiaie? n ?aiaa i?eiaiyaoeieny iaoeaioaie neeuiu-
ie iieieaaie e a 1/3 neo?aaa aiaeiae?iu.
Aicieea?uea a ?aaeeo neo?ayo iiai?iua yooaeou (oioiioa,
aai?anney auoaiey, caii?u) iiaaa?ony ei??aeoee iooai iacia-
?aiey neiioiiaoe?aneeo n?aanoa eee nie?aiey aicu a??iaace-
ea. Ia?aiineiinou oa?aiee a??iaaceeii aieuoeinoaii aieu-
iuo ioaieaaaony eae eo?oay ii n?aaiaie? n oa?aieae a?oaeie
neeuiuie iieieaaie. I?aaii?oaiea a??iaaceeo ia?aa i?a?iae
iieieaiie eee iaiieieaiie oa?aieae ioaaao iiaaaey?uaa
aieuoeinoai iaoeaioia a nayce n eo?oae aiaeaaceae e oaiano-
aii oa?aiee.
O?ainaa?iaeuiay oa?aiaaoe?aneay nenoaia «A??iaacee» ii-
iiaaao oeo?oeou ea?anoai iiiiue eieo?aaaeuiui iieieiae?an-
eei iaoeaioai, no?aaa?uei neeuiui OAN. Yoio i?aia?ao nea-
aoao eiaou a ?enea n?aanoa iaacaieeaaiey aey aaiiiai eiioei-
aaioa iaoeaioia eae iaeaieaa yooaeoeaiue, oi?ioi ia?aiine-
iue e oaiaiue aey oy?aeiaieuiuo.
Ëèòåðàòóðà
1. Îñèïîâà Í.À., Íîâèêîâ Ã.À., Ïðîõîðîâ Á.Ì. Õðîíè÷åñ-
êèé áîëåâîé ñèíäðîì â îíêîëîãèè. — Ì. — «Ìåäèöèíà».
— 1998. — 183 ñ.
2. Berger A., Hoime Ñ., Saberski L., Zeiterman D. Controlled
Release Oral Morphine (MS Cont. Tablets) versus Fentanyl
Transdermal System (Durogesic) for the Outpatient Treatment
of Cancer Pain/Abstracts 8th World Congress on Pain, Van-
couver, Canada. — 1996. — P.21.
3. Durogesic R004263 Investigator's Brochure, Janssen Research
Foundation, Second Ed. — 1998.
4. fnlcia dc V., AriaK L.M., PahimarcK G. Evaluation of TTS-
Fcnt.anyl in Adult Patirnt.s with Cancer Pain/Abstracts 8
th
World Congress on Pain. Vancouver. Canada. — 1996. —
P.21-22.
5. Georges G.B., Moraes T.M., Mota M.F., Coeli S.M.C. Fen-
tanyl-TTS for Treatment of Cancer Pain/Abstracts 8
th
World
Congress on Pain. Vancouver. Canada. — 1996. — P.22.
6. Go/ã C.R. Routes of Opioid Administration: the Role of Sub-
lin-gual/Buccal, Transdermal and Parenteral Infusion Thera-
py. In: Pain 1996 — an Updated Review. Refresher Curse Syl-
labus, IASP Press, Seattle. — 1996. — P.247-251.
7. Lee S.C., Kirn J.K., Kirn D.H. Analgesic effect and safety of
Transdermal Fentanyl Patch Comparing with Oral Morphine,
«Pain in Europe», Book of Abstracts II Congress of the Europ.
195
Àíòîëîãèÿ íàó÷íûõ ïóáëèêàöèé
Ðèñ. 4.
Îöåíêà ïàöèåíòàìè êà÷åñòâà àíàëãåçèè, ïåðåíîñèìî-
ñòè è óäîáñòâà òåðàïèè ÒÒÑ «Äþðîãåçèê» (ñòîëáöàìè ïîêàçàíî
àáñîëþòíîå ÷èñëî ïàöèåíòîâ)
