tase in the follow — up of bone metastases in breast cancer//
Int. J. Biol. Markers. — 1990. — 5 (2). — P.65-72.
23. Galasko C.S. Incidence and distribution of bone metastases//
Clin. Orthop. — 1986. — 210. — P.14-21.
24. Hoogstraten B. Adriamycin (NSC-123127) in the treatment of
advanced breast cancer: studies by the Southwest Oncology
Group// Cancer Chem. Rep. — 1980. — Part 3, 6. — ¹ 2. —
P. 329-496.
25. Hortobahyi G.N., Frifsche H.A. Carcinoembrionic antigen in
breàst cancer// Cancer Bull. — 1985. — V. 37. —¹ 2. — P.58-
60.
26. Horton Y. Follow-up of breast cancer patients// Cancer. —
1984. — V. 53. — 3. — P.790-797.
27. Loprinzi C.L., Tormey D.C., Rasmussen P. et al. Prospective
evalution of carcinoembryonic antigen levels and alternating
chemotherapeutic regimens in metastatic breast cancer// J.
Clin. Oncol. — 1986. — 4. — P.46-56.
28. Mughal A.W., Hortobagyi G.N., Fritsch H.A. et al. Serial plas-
ma carcinoembryonic antigen level measurements during
treatment of metastatic breast cancer// J.A.M.A. — 1983.-
249. — P.1881-1886.
29. O`Brien D.P., Horgan P.G., Gough D.B. CA 15-3: a reliable
indicatos of metastatic bone disease in breast cancer patients//
Ann. R. Coll. Surg. Engl. — 1992. — 74 (1). — P. 9-11.
30. Radbruch L., Zech D., Grond S. Therapy for symptomatic
pain in advanced breast cancer// Geburtshilfe Frauenheilkd.-
1992. — 52 (7). — P.404-411.
31. Shinozaki T., Chifira M. Diagnosis of skeletal metastases by
serum tumor markers// Nippon. Seikeigera Gakkai Zasshi. —
1991. — 65 (8). — P.441-446.
32. Stoll B.A. Does the malygnancy of breast cancer vary with
age?// Clin. Oncol. — 1976. — V. 2. —¹ 1. — P.73-80.
33. Twycross R.G., Fairfield S. Pain in far-advanced
cancer//Pain. — 1982. — 14. — P. 303-310.
Iaeeeaoeaiay iaaeoeia e ?aaaeeeoaoey, 2000, ¹ 3, no?. 5-11.
ÒÐÀÍÑÄÅÐÌÀËÜÍÀß ÒÅÐÀÏÅÂÒÈ×ÅÑÊÀß
ÑÈÑÒÅÌÀ ÔÅÍÒÀÍÈËÀ
I.A. Ineiiaa, A.A. Iiaeeia, A.I. I?ioi?ia, I.A. Aaeniai,
A.?. Aaoca?iaa, I.A. Einaaa
Iineianeee iao?ii-enneaaiaaoaeuneee iieieiae?aneee
einoeooo ei. I.A. Aa?oaia
Niaa?oainoaiaaiea iaeiaaceaiuo niiniaia aaaaaiey iiei-
eaia a i?aaieci ?aeiaaea yaeyaony iaiie ec aeooaeuiuo i?ia-
eai oa?iaeioa?aiee o?iie?aneie aiee a iieieiaee. Oe?iei
?ani?ino?aiaiiue o?aaeoeiiiue i?aeuiue ioou aaaaaiey iiei-
eaia ia?aaei iai?eaieai o iieieiae?aneeo aieuiuo n iiooiey-
ie ?yaa eieaeecaoee (?ioiaeioea, ieuaaia, ?aeoaie) [1]. A?oaea
ecaanoiua iaeiaaceaiua iooe aaaaaiey iieieaia (noaeeiaaaeu-
iue, aoeeaeuiue, ay?icieuiue, ?aeoaeuiue) iiaoo auou eniieu-
ciaaiu oieuei i?e iaeioi?uo iieieaiuo aaiienoao-aioaaiienoao
e aaiienoao (aoi?aii?oei, aooi?oaiie, i?ineaae) e eia?o ia?a-
ie?aiey aey iaeaieaa iiuiuo aaiienoia ii?oeiiaiai ?yaa
aaeao iaainoaoi?iie aeionaiyaiinoe, ai?ueiai aeona e a?. [6]
?acoeuoaoii iienea iiauo iaeiaaceaiuo oi?i neeuiuo ii-
iieaia yaeeanu o?ainaa?iaeuiay oa?aiaaoe?aneay nenoaia
(OON) oaioaieea — «A??iaacee» («?innai-Neeaa», Aaeuaey).
Oa?aeoa?enoeea OON-«A??iaacee».
A??iaacee i?aanoaaey-
ao niaie nenoaio aey o?ainaa?iaeuiiai iinoiyiiiai iinooiea-
iey oaioaieea a i?aaieci iaoeaioa. Nenoaia niaa??eo iaeeae-
aaaio? ia ei?o n iiiiuu? ieanou?y eciee?iaaiio? eaia?o,
caee??a?uo? a naaa i?aia?ao oaioaiee oeo?ao (2,5 ia/10 ni
2
),
aeeiaieu (0,1 ia/10 ni
2
) e aea?ieneyoeeoaee?eico, nicaa?uo?
?aeaia?acio? eiinenoaioe?. Iaia?aia eaia?u aaoa?ieie?oao
iauai iinooieaiey i?aia?aoa, eioi?ue ii?ao ninoaaeyou 25,
50, 75 eee 100 iea/? a caaeneiinoe io ieiuaae nenoaiu (10, 20,
30 eee 40 ni
2
), ?oi niioaaonoaoao nooi?iie aica oaioaieea 0,6,
1,2, 1,8 eee 2,4 ia/noo. (?en. 1). Inoaeuiua eiiiiiaiou nenoaiu
oa?iaeieiae?anee iaaeoeaiu. Oaioaiee, aeoooiae?oy ?a?ac ei-
?o, nicaaao iiaei?iia aaii, ioeoaa iinoaiaiii iinooiaao a e?i-
aioie (?en. 2).
Oaioaiee eae iiuiue iieieaiue aaiieno ?aoaioi?ia i?aai-
noiaeo ii aiaeuaaoe?aneiio iioaioeaeo ii?oei a 75-100 ?ac e
i?aaiacia?ai aey ono?aiaiey iaeaieaa neeuiie aiee. Ii aai-
iui ?ac?aaio?eeia OON «A??iaacee» [3], io iiiaioa oeenaoee
ieanou?y ia ei?a (i?aaii?oeoaeuii ia?aaiae iiaa?oiinoe a?o-
ae) ai ia?aea aiaeuaaoe?aneiai aaenoaey i?aia?aoa i?ioiaeo 8-
12 ?, noaaeeuiay eiioaio?aoey oaioaieea a nuai?ioea ainoeaaao-
ny ia?ao 12 e 24 ?anaie, a i?iaie?eoaeuiinou yooaeoa ea?ai-
ai ieanou?y ninoaaeyao 72 ?. Ieieiaeuiay yooaeoeaiay aiaeu-
aaoe?aneay eiioaio?aoey oaioaieea ninoaaeyao io 0,3 ai 1,5
ia/ie; iiai?iua yooaeou oaioaieea ia?eia?o i?iyaeyouny i?e
eiioaio?aoee e nuai?ioea 2 ia/ie. I?e aeeoaeuiii aaaaaiee
oaioaieea oeacaiiua eiioaio?aoee iiaoo oaaee?eaaouny ca n?ao
?acaeoey oiea?aioiinoe e i?aia?aoo, naienoaaiiie anai iieie-
aai.
Iiai?iua yooaeou oaioaieea aiaeiae?iu i?enouei a?oaei
neeuiui iieieaai. Iiaoo ?acaeaaouny oioiioa, ?aioa, caii?u,
niieeainou, aai?anney auoaiey, i ?ai iaoeaiou aie?iu auou
i?aaoi?a?aaiu. Iaeaieaa iianiia iiai?iia aaenoaea oaioaie-
192
Àíòîëîãèÿ íàó÷íûõ ïóáëèêàöèé
Ðèñ. 1.
Ñõåìà ÒÒÑ Äþðîãåçèê.
Ðèñ. 2.
Òðàíñïîðò ôåíòàíèëà â êðîâåíîñíîå ðóñëî èç ÒÒÑ
Äþðîãåçèê.
