ÝÍÄÎËÈÌÔÀÒÈ×ÅÑÊÀß ÕÈÌÈÎÒÅÐÀÏÈß
ÁÎËÜÍÛÕ Ñ ËÈÌÔÎÃÅÍÍÛÌÈ
ÌÅÒÀÑÒÀÇÀÌÈ ÐÀÊÀ ÏÐßÌÎÉ ÊÈØÊÈ
A.I. ?oeia, A.E. Naaeieia, A.?. Enaaa, I.?. Aieaeo, A.A. ?a?iia
Naia?neee ia?aaaiinoaaiiue IEE «Iaeiiece?o?uea
eceo?aiey a iaaeoeia»
Iia iaae?aaieai iaoiaeeenu 220 aieuiuo ?aeii i?yiie
eeoee (114 io??ei, 106 ?aiuei), eioi?ui auee i?iaaaaiu ?ac-
ee?iua iia?aoee. O anao iaoeaioia auea onoaiiaeaia III eee IV
eeeie?aneay a?oiia caaieaaaiey.
Aaaaaiea a eeioaoe?aneia ?onei ie?ieo eiia?iinoae oeoi-
noaoe?aneeo i?aia?aoia n oaeu? nicaaiey eo iaiin?aanoaaiiiai
eiioaeoa n iaoanoacaie ?aeiaie iiooiee, oeene?iaaiiuie a
eeioaoe?aneeo oceao eee iea?e?o?ueie n oieii eeiou, n oai?a-
oe?aneie oi?ee c?aiey yaeyaony iainiiaaiiui iaoiaii ea?aiey.
O 122 aieuiuo auiieiaia i?aaiia?aoeiiiay e iineaiia?aoe-
iiiay aaonoi?iiiyy yiaieeioaoe?aneay oeieioa?aiey (YOO).
Eo?n ea?aiey a aiiia?aoeiiiii ia?eiaa ninoiye ec aaoo i?ioa-
ao? n eioa?aaeii aaaaaiey oeoinoaoe?aneeo i?aia?aoia a 7 aiae.
A iineaiia?aoeiiiii ia?eiaa — 3 aaaaaiey ?a?ac 21 aaiu.
A ?acoeuoaoa i?iaaaaiiuo enneaaiaaiee iieo?aiu aaiiua i
aeaaii?eyoiii aaenoaee YOO a i?aaiia?aoeiiiii e iineaiia-
?aoeiiiii ia?eiaao ia aaeoa?eaeuiue noaoon e ?oanoaeoaeu-
iinou iee?iaiie oei?u e aioeaeioeeai oe?ieiai niaeo?a aae-
noaey. A ?anoiinoe, a iineaiia?aoeiiiii ia?eiaa eiaei ianoi
oiaiuoaiea (ai 52% iaae?aaiee) ?anoiou iaaiiaiey i?iia?-
iinoiuo ?ai ca n?ao nie?aiey eiioaio?aoee a ?aiao no?aioi- e
noaoeeieieeiaie oei?u. Oiaiuoeeinu a 2-3 ?aca eiee?anoai ia-
ae?aaiee aunaaaiey neiaaiieiie iaei?ee, a 2 ?aca — noaoeei-
eieea e no?aioieieea e annioeaoee iee?iaiie oei?u. O 53% ia-
oeaioia ia auyaeai ?ino iee?ii?aaieciia a ?aia. Oaaee?eeinu
eiee?anoai iaae?aaiee (ai 54%) aunieie ?oanoaeoaeuiinoe ie-
e?ioei?u e aioeaeioeeai oe?ieiai niaeo?a aaenoaey a ?acoeu-
oaoa i?iaiaeiiai ea?aiey.
Iiei?eoaeuiia cia?aiea eiaao i?aaiia?aoeiiiay aaonoi-
?iiiyy YOO. Iia niinianoaoao a?aiaiiie caaa??ea ?acaeoey
iiooiee, i?aaioa?auaie? iaoanoace?iaaiey ai a?aiy iia?a-
oee ii eeioaoe?aneei ninoaai e aaeuiaeoae eiaacee iiooiea-
auo eeaoie, ?oi iiauoaao yooaeoeaiinou oe?o?ae?aneiai aia-
oaoaeunoaa.
Ii iaoei aaiiui, aieuoeinoai oeoinoaoe?aneeo i?aia?aoia
iaeaaaao au?a?aiiui i?ioeaiainiaeeoaeuiui yooaeoii.
A iineaiia?aoeiiiii ia?eiaa YOO iacia?a?o n oaeu? i?i-
oeeaeoeee iaoanoacia e ?aoeaeaia iiooiee. Ea?aiea oaeaniia-
?acii inouanoaeyou eo?naie 2 ?aca a aia. Aii?in i a?aiaie
i?iaaaaiey yoie oa?aiee ?aoaaony eiaeaeaoaeuii.
Oaeei ia?acii, iaoia aaonoi?iiiae yiaieeioaoe?aneie oe-
ieioa?aiee i?aaiacia?ai aey aicaaenoaey ia iaii ec iniiaiuo
iaoiaaiaoe?aneeo caaiuaa o aieuiuo ?aeii i?yiie eeoee. Ii
aeiee?oao iaoanoace?iaaiea ec ?aaeiia?iuo eeioaoe?aneeo oc-
eia. Yoi, a eiia?iii n?aoa, i?eaiaeo e oaaee?aie? i?iaie?e-
oaeuiinoe ?ecie aieuiuo ii n?aaiaie? n eiio?ieuiie a?oiiie
ia 52%.
III Eiioa?aioey «Iaeeeaoeaiay iiiiuu a iieieiaee», ai?aeu, 1997,
?eoa, Iaeeeaoeaiay iaaeoeia e ?aaaeeeoaoey, 1997, ¹ 2, n. 28-29.
ÏÀËËÈÀÒÈÂÍÎÅ ËÅ×ÅÍÈÅ ÐÀÊÀ ßÈ×ÍÈÊÎÂ
A.A. Eiiiiia, A.A. Cieioeia, A.I. Iiiia, A.O. Nieoui,
I.I. Aoi?ay, ?.A. Oe?nia, A.A. Eaiaoia
A?oaiaaeuneay ainoaa?noaaiiay iaaeoeineay aeaaaiey,
A?oaiaaeuneee iaeanoiie eeeie?aneee iieieiae?aneee aeniaina?
Iaeeeaoeaiia ea?aiea ?aea ye?ieeia i?aanoaaeyao niaie
i?aiu aa?io? i?iaeaio. Ionoonoaea ?aiieo niaoeoe?iuo nei-
ioiiia caaieaaaiey e ai?iaiaecia ne?eieiaiauo iaoiaia i?e-
aiayo e aunieie caiouaiiinoe aaiiie iaoieiaee, a oniao a ea?a-
iee ?aea ye?ieeia anaoaei caaeneo io ?aaeeaeuiinoe i?iaaaai-
iiai iia?aoeaiiai aiaoaoaeunoaa. Aicii?iinou ?a auiieiaiey
?aaeeaeuiie iia?aoee i?e III noaaee iaauniea: 10 — 15%.
Ca ia?eia 1988-92 aa. a A?oaiaaeuneii iaeanoiii iieieiae?a-
neii aeniaina?a (AIIA) i?iea?aiu 252 aieuiuo ?aeii ye?ie-
eia, ec ieo 86 (34%) aieuiuo eiaee III noaae? caaieaaaiey, 100
(39%) aieuiuo — IV. Oaeei ia?acii, iieacaoaeu caiouaiiinoe
ninoaaee 73%. Anaai i?iiia?e?iaaiu 140 (55%) aieuiuo, a oii
?enea ?aaeeaeuii — 76 (30%), ia?aaeeaeuii — 64 (25,5%). Ec
iauaai ?enea aieuiuo a III noaaee caaieaaaiey ?aaeeaeuii i?i-
iia?e?iaaiu 10 (11,6%) aieuiuo. Oieuei oeieioa?aie? iieo?e-
ee 63 (25,4%) aieuiuo, o 49 (19,2%) aieuiuo auea i?iaaaaia
eeou neiioiiaoe?aneay oa?aiey.
O?eouaay oy?aeia iauaa ninoiyiea aieuiuo e ?ani?ino?a-
iaiiinou iiooieaaiai i?ioanna, iia?aoeaiia aiaoaoaeunoai n
iaeeeaoeaiie oaeu?, o.a. iaeneiaeuii aicii?iia oaaeaiea iio-
oieaauo iann, auei inouanoaeii o 64 (34,4%) aieuiuo ?aeii
ye?ieeia III — IV noaaee. Oaeei ia?acii, aicii?iinoe oe?o?ae-
?aneiai iaoiaa a iaeeeaoeaiii ea?aiee neeuii ia?aie?aiu. A
nayce n yoei aic?anoaao ?ieu oaeeo iaoiaia ea?aiey, eae oe-
ieioa?aiee e eo?aaiai ea?aiey.
Oeieioa?aiey ia?yao n oe?o?aeae yaeyaony aaciaui iaoi-
aii ea?aiey aieuiuo ?aeii ye?ieeia e i?e neeuii caiouaiiii
i?ioanna inoaaony ia aaiiue iiiaio aaeinoaaiiui iaoiaii,
aa?uei iaaa?ao ia oeo?oaiea eee noaaeeecaoe? caaieaaaiey.
A AIIA n iaeeeaoeaiie oaeu? i?eiaiyeenu ?acee?iua noaiu
oeieioa?aiee: CMF, CAP, iiiioeieioa?aiey oeeeioinoaie-
aii. Ioia?aii oaaee?aiea ?enea oeo?oaiee (?aci?aoey iiooiee
aieaa 50%) o aieuiuo a III noaaee i?e i?eiaiaiee noai n aee?-
?aieai i?aia?aoia ieaoeiu ii n?aaiaie? ni noaiie CMF: 35 e
25% niioaaonoaaiii. Iaiaei o 7% aieuiuo, iieo?aaoeo noaio
CAP, ea?aiea auei i?a?aaii ec-ca ?acaeaoeony inei?iaiee.
O?aoeaoiyy au?eaaaiinou aieuiuo i?e III noaaee i?ioanna auea
oae?a auoa i?e i?eiaiaiee noaiu CAP ii n?aaiaie? n CMF:
niioaaonoaaiii 23 e 17%. Ia ioia?aii ?acee?ee a n?aaiae i?i-
aie?eoaeuiinoe ?ecie aieuiuo ?aeii ye?ieeia IV noaaee, eioi-
?ay ninoaaeea 7,4 ian, i?e i?eiaiaiee ?acee?iuo noai oeiei-
oa?aiee. Niaeanii aaiiui eeoa?aoo?u, ii?ii iieo?eou na?uac-
iia oaaee?aiea ?enea oeo?oaiee e noaaeeecaoee i?ioanna i?e
i?eiaiaiee aioo?eiieinoiiai aaaaaiey i?aia?aoia ieaoeiu,
?oi iicaieyao iiaaanoe aunieea aicu i?aia?aoa iaiin?aanoaai-
ii e iaoieiae?aneiio i?aao.
A iineaaiaa a?aiy ana aieaa i?enoaeuiia aieiaiea oaaey-
aony eo?aaie oa?aiee ?aea ye?ieeia, iniaaiii i?e ia?aie?ai-
iuo eioeeuo?aoao a iaeii oaco, eioi?ua ia oaaaony oaaeeou oe-
?o?ae?aneei iooai. Iniiaiie i?iaeaiie, eeieoe?o?uae i?e-
iaiaiea eo?aaie oa?aiee i?e ?aea ye?ieeia, yaeyaony aunieay
?oanoaeoaeuiinou i?aaiia ?EO e aicaaenoae? eiiece?o?uaai
eceo?aiey. N iaoae oi?ee c?aiey, ianoaiaa?oiue ?a?ei o?ae-
oeiie?iaaiey aicu — 1,25 A? aaa?au a aaiu n eioa?aaeii 4 ? ai
NIA 45 A? — iicaieeo oiaiuoeou iaa?oceo ia ii?iaeuiua oea-
ie e oaaee?eou ii?a?aaiinou iiooiee. Ieaiiaia aee??aiea eo-
?aaie oa?aiee a noaiu iaeeeaoeaiiai ea?aiey neeuii caiouai-
iiai ?aea ye?ieeia aie?ii i?eaanoe e oeo?oaie? iieacaoaeae
au?eaaaiinoe aieuiuo.
III Eiioa?aioey «Iaeeeaoeaiay iiiiuu a iieieiaee», ai?aeu, 1997,
?eoa, Iaeeeaoeaiay iaaeoeia e ?aaaeeeoaoey, 1997, ¹ 2, n. 20.
ÏÀËËÈÀÒÈÂÍÎÅ ËÅ×ÅÍÈÅ ÍÅÄÈÔÔÅÐÅÍÖÈ-
ÐÎÂÀÍÍÛÕ ÔÎÐÌ ÐÀÊÀ ËÅÃÊÎÃÎ
A.A. Eiiiiiaa, A.A. Cieioeia, I.I. Aoi?ay, N.I. Anaoei,
B.A. Aeeoei, E.E. Iooea?aaa, A.I. Eoeeeia
A?oaiaaeuneee iaeanoiie eeeie?aneee iieieiae?aneee aeniaina?
Ecaanoii, ?oi iaaeooa?aioe?iaaiiue ?ae eaaeiai (iaeei-
eeaoi?iue, aiaieanoe?aneee, e?oiiieeaoi?iue) i?aiu auno?i
i?ia?anne?oao, ?aii e iaoe?ii iaoanoace?oao. A nayce n yoei a
ianoiyuaa a?aiy ii?ii eiinoaoe?iaaou eeou aai iaeeeaoeaiia
500
Àíòîëîãèÿ íàó÷íûõ ïóáëèêàöèé
