of the life quality in the group of oncopatients at the final stage of the dis-
ease have been made by «Mundipharma» eterprise, which developed and
represented several analytics with pro-longated function. Tramundin,
MST-ñontinuus, DHC-ñontinuus are among them.
Conclusion, that prolongated form of morphine in tablets is a high
effective analgetic, which is very good in the management of chronic pain
syndrome in oncopatients at the IV stage of the disease, is based on the
experience of the use of these tablets every 12 hours. Tableted drug-form
and prolongated action make this medicine mainly useful in this group of
patients. Side effects are easy to treat or to prevent. Depression of the
spontaneous breathing and developement of drug-dependence have
never been observed.
Iaiei ec aa?iaeoeo aii?inia aeiiaaeoeineie yoeee yaeyao-
ny i?iaeaia ieacaiey iaeeeaoeaiie iiiiue eieo?aaaeuiui ii-
eieiae?aneei aieuiui, o.a. aieuiui, aaciaaa?iui a ieaia ia?-
niaeoeau i?iaie?eoaeuiinoe ?ecie. Iniiaiie e, ii?aeoe, aaei-
noaaiii auiieieiie caaa?ae ieacaiey iiiiue yoie oy?aeie ea-
oaai?ee iaoeaioia yaeyaony iiauoaiea ea?anoaa eo ?ecie. Yoio
aniaeo oanii ia?aieaoaaony n ea?anoaii ?ecie e cai?iauo ?ea-
iia naiue, ?ianoaaiieeia, a?ocae, ie?o?a?ueo aieuiiai.
Iiaieiay aii?in ia yoeea a ioiioaiee e iieieiae?aneei
aieuiui, oi?aony aua ?ac inoaiiaeouny ia iaeioi?uo, eacaeinu
au i?aaeaiuo, iiei?aieyo. A naiai ioiioaiee e aaciaaa?iui
aieuiui i?aiu aa?ii ?oeiaianoaiaaouny oaeeie yoe?aneeie
niia?a?aieyie, eae oaa?eoaeuiia ioiioaiea e ?ecie aieuii-
ai, e aai naiinoiyoaeuiinoe, e aai ainoieinoao. Iaiaoiaeii noa-
?aouny oiaei eniieuciaaou inoaaoeany a ?anii?y?aiee aieu-
iiai nouanoaaiii eeieoe?iaaiiua oece?aneea, ineoe?aneea e
yiioeiiaeuiua ?ano?nu. Iineaaiea ianyou nouanoaiaaiey
aieuiuo, anee iie i?aauaa?o ia a noaoeiia?a, a aiia, i?ioaea-
?o a aanuia oyainoiie ianoaiiaea. A aaau eiaiii a yoii ia?ei-
aa aieuiie aieuoa anaai io?aaaony a ainoaoi?ii iiiaiia?ac-
iuo oi?iao iaeeeaoeaiie oa?aiee. Iiauoay ea?anoai ?ecie
aieuiiio, iu oai naiui oeo?oaai ea?anoai ?ecie oaeie a?oi-
ia e?aae, iia?an aiaieuii iiiai?eneaiiie. Auiieiyy yoo ai-
aieuii aa?io? e cia?eio? caaa?o, iu noaeeeaaainy n ?yaii
i?iaeai, eioi?ua eia?o e naia yoe?aneia au?a?aiea. Iniia-
iui e iaeaieaa ?anoui i?iyaeaieai iieieiae?aneiai caaiea-
aaiey yaeyaony aieu. ?oi oaeia aieu o ?aeiaiai aieuiiai? Ia-
a?ya ee eiio-ieaoau neaaoao yoi iauyniyou. Ii?aeoe, ii?oe ea-
?aue ec ?eoaoaeae eiae aicii?iinou yoi iaae?aaou. Ii noaoe-
noe?aneei aaiiui Anaie?iie i?aaiecaoee ca?aaiio?aiaiey
a?aaiaaii a ie?a no?aaa?o io aiee ieiei 3,5 iei. iieieiae?a-
neeo aieuiuo, a ?inneeneie Oaaa?aoee ?enei eo ninoaaeyao ai-
eaa 300 oun. ?aeiaae.
Eiaiii i?eaaiea aiee yaeyaony aeaaiui, ?oi aucuaaao
no?ao, niyoaiea e iaieeo, ?oi oae ioaaao e?aae, eiaaa iie neu-
oao ?ieiaie aey naay aeaaiic «?ae». Aieu e eiaiii aieu iaii-
neo nie?ooeoaeuiue oaa? ii ?aeiaa?aneiio niciaie?, eiaaa
aieuiie ia aeaeo, ia neuoeo e ia ?oanoaoao ie?aai, e?iia iinoi-
yiiie aiee. Aieu naiaeo ia iao ia?aie?aiiua aieaciu? ?eciai-
iua ?ano?nu iaoeaioa. Ono?aiaiea aiee — yoi ia oieuei oiaiu-
oaiea no?aaaiee aieuiiai, ii e nicaaiea iioeiaeuiuo oneiaee
ia inoaaoeeny ia?eia ?ecie.
Iaiei ec iniiaiuo i?eioeiia ea?aiey o?iie?aneiai aieaai-
ai neia?iia o iieieiae?aneeo aieuiuo a oa?ieiaeuiie noaaee
caaieaaaiey yaeyaony eniieuciaaiea aiaeuaaoe?aneeo i?aia?a-
oia ii onoaiiaeaiiie noaia, a ia ii ia?a aicieeiiaaiey aiee,
o.a. «ii ?anai», a ia «ii o?aaiaaie?» [1]. Aicii?iinoe niae?-
aaiey yoiai i?eioeia a cia?eoaeuiie noaiaie caaenyo io ?aao-
ey?iiai i?eaia iaacaieeaa?ueo i?aia?aoia, iniaaiii, anee
?a?u eaao i ia?aioa?aeuiii eo aaaaaiee. Iniiaiua o?oaiinoe
aicieea?o ia?aa no?aaa?ueie io aiee iieieiae?aneeie aieu-
iuie, iaoiayueieny a aiiaoieo oneiaeyo. Iaaicii?iinou ?a-
aoey?iiai aaaaaiey iaacaieeaa?uaai i?aia?aoa ii noaia iao-
neiaeaia a ia?ao? i?a?aau oai, ?oi aaeaei ia anaaaa iao?iia-
?iay (o?anoeiaay) iaaeoeineay nano?a ii?ao iinauaou aieuii-
ai ianeieuei ?ac a aaiu a niioaaonoaee n nouanoao?uei a?aoe-
eii aaaaaiey iaacaieeaa?ueo i?aia?aoia. Iau?ii iia i?eoi-
aeo 1 ?ac a aaiu, eiaaa ae yoi oaiaii, eee aaeaao eiuaeoee 2 ?aca
a aaiu — oo?ii e aa?a?ii. Aaaaaiea aiaeuaaoeeia «ii ?anai»,
o.a. ii ii?aaaeaiiie 4- eee 6-?aciaie noaia eo?oa inouanoaey-
aony a oao neo?ayo, eiaaa ?ianoaaiieee aieuiiai naie iaeaaaaa-
?o iaoiaeeie eiuaeoee iaacaieeaa?ueo i?aia?aoia.
Iieacaii, ?oi ia?eiaou ea?aiea o?iie?aneie aiee neaaoao n
iaia?eioe?aneeo aiaeuaaoeeia, e ainoe?u aaaeaaoiiai iaacaiee-
aaiey i?e yoii aicii?ii o 45% iaoeaioia. Iaiaei e enoiao 12-
e iaaaee yooaeoeaiinou yoiai ea?aiey nie?aaony ianoieuei, ?oi
i?eoiaeony i?eaaaaou e eniieuciaaie? neaauo, a caoai e neeu-
iuo iieaoia. I?eiaiaiea yoie a?oiiu aiaeuaaoeeia a iineaaiaa
a?aiy iaoiaeo ana aieuoaa e aieuoaa ?ani?ino?aiaiea. A ia?-
ao? i?a?aau yoi naycaii n eo aunieie aiaeuaaoe?aneie yooae-
oeaiinou?, a oae?a iiyaeaieai iieaoia a iiaie eaea?noaaiiie
oi?ia, iaeaieaa oaiaiie aey eniieuciaaiey a ea?aiee o?iie?a-
neie aiee o eieo?aaaeuiuo iieieiae?aneeo aieuiuo. Yoi — oaa-
eaoee i?ieiiae?iaaiiiai aaenoaey. I?eaeiaeuiia ?aciauaiea
aaenoao?uaai ia?aea ia iao?eoa aea?ieneaeeeeuiie oaee?ei-
cu e aunoeo aeeoaoe?aneeo nie?oia iicaieyao iaeaieaa yooae-
oeaii eniieuciaaou aiaeuaaoe?aneee yooaeo iieaoia n iaeiaiu-
oei i?iyaeaieai eo iiai?iuo aaenoaee. Oaaeaoee i?ieiiae?i-
aaiiiai aaenoaey auionea?ony a ?acee?iie aice?iaea, ?oi iic-
aieyao eiaeaeaoaeuii iiaia?aou aico aey aaaeaaoiiai iaacai-
eeaaiey. Iinoaiaiiinou ?aaeecaoee aaenoao?uaai ia?aea iic-
aieyao, n iaiie noi?iiu, ecaa?aou «ieeiaie» eiioaio?aoee i?a-
ia?aoa a ieacia e?iae e iiaaa??eaaou eiioaio?aoe? ia iaia-
oiaeiii aey iaacaieeaaiey o?iaia, a, n a?oaie noi?iiu, — i?i-
aeeou n?ie aiaeuaaoe?aneiai aaenoaey i?aia?aoa ai 12 ?. Oaeei
ia?acii, aiaeuaaoeee i?ieiiae?iaaiiiai aaenoaey a aeaa oaa-
eaoie yaey?ony i?aia?aoaie ia?aie eeiee a ea?aiee o?iie?an-
eiai aieaaiai neia?iia o iieieiae?aneeo aieuiuo, iniaaiii a
aiiaoieo eee aiaoeaoi?iuo oneiaeyo.
Iaiei ec aicii?iuo iiai?iuo i?iyaeaiee iieaoia, aa?a ii
iiaie? iiiaeo iaaeoeineeo ?aaioieeia, ia aiai?y o?a i aieu-
iuo e eo ?ianoaaiieeao, yaeyaony ?acaeoea ineoieiae?aneie ca-
aeneiinoe eee ia?eiiaiee. Iaiaei iiiai?eneaiiua eeeie?an-
eea iaae?aaiey, ioaeeeaoee ca?oaa?iuo aaoi?ia, a oae?a iao
iiuo naeaaoaeunoao?o i oii, ?oi ?ene aicieeiiaaiey aaiiiai in-
ei?iaiey ie?oi?ii iae o iieieiae?aneeo aieuiuo, iaoiayueo-
ny a oa?ieiaeuiie noaaee caaieaaaiey, e ninoaaeyao ia aieaa,
?ai 0,1% [5], a ii a?oaei aaiiui yoi yaeaiea auei ioia?aii
eeou o 7 ec 24000 iaoeaioia [6]. Iu a naiae i?aeoeea n iiaia-
iui inei?iaieai ia ano?a?aeenu.
Cia?eoaeuiue aeeaa a ?aoaiea i?iaeaiu oeo?oaiey ea?ano-
aa ?ecie iieieiae?aneeo aieuiuo ia iineaaiae noaaee caaiea-
aaiey aianea iaia ec aaaoueo a ie?a oa?iaoaaoe?aneay oe?ia
«Ioiaeoa?ia», ?ac?aaioaaoay e oe?iei i?aanoaaeaoay ia
?uiea ?ya aiaeuaaoeeia i?ieiiae?iaaiiiai aaenoaey. A eo ?en-
ea Tramundin, MST-nontinuus, DHC-nontinuus.
Tramundin
— i?aia?ao, ecaanoiue e oe?iei eniieucoaiue a
?innee iia iacaaieai o?aiae eee o?aiaaie. I?aia?ao yooaeoe-
aai i?e oa?aiee o?iie?aneie aiee ia yoaia aa ea?aiey neaauie
iieaoaie. ?aoa?aiay aai oi?ia, ?ac?aaioaiiay oe?iie, iieo-
?eea iiaia i?eaeiaeuiia iacaaiea.
DHC-nontinuus
— aaenoao?uei ia?aeii i?aia?aoa yaeyao-
ny aeaea?ieiaaei. I?eiaiyaony i?e ea?aiee o?iie?aneie aiee
n?aaiae e neeuiie eioaineaiinoe, a oae?a eiaaa aicii?iinoe
ea?aiey o?aioiaeiii en?a?iaiu.
MST-nontinuus
— i?iecaiaiia ii?oeia noeuoaoa, iaei ec
iaeaieaa neeuiuo iieaoia ii naiaio aiaeuaaoe?aneiio aaeno-
ae?. I?aia?ao eniieucoaony i?e ea?aiee neeuiie aiee e niio-
aaonoaoao i?aia?aoai 3-e nooiaie «aiaeuaaoe?aneie eanoieou» a
ea?aiee o?iie?aneiai aieaaiai neia?iia o iieieiae?aneeo
aieuiuo.
O?a iaii oi, ?oi iaia eee ianeieuei oaaeaoie aaiiuo i?aia-
?aoia iiaoo ecaaaeou aieuiiai io iaauiineiie aiee ia n?ie ai
12 ?., aaeaao eo iaeneiaeuii oaiaiuie i?e ea?aiee o?iie?aneie
iieieiae?aneie aiee. I?aaeeuii iiaia?aiiay aica iicaieyao
iaania?eou aaaeaaoiia iaacaieeaaiea i?e ieieiaeuiii iiai?-
iii aaenoaee. Iiai?iua i?iyaeaiey, oa?aeoa?iua aey iieieaia
(oioiioa, caii?u, naaaoeaiinou), ii?ii i?aaoi?aaeou niioaaono-
ao?ueie i?ioeeaeoe?aneeie ia?ii?eyoeyie e i?aia?aoaie.
A nayce n oai, ?oi aaiiua i?aia?aou a iineaaiaa a?aiy ana
?aua e ?aua noaee iiyaeyouny ia ioa?anoaaiiii aioa?iii ?ui-
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Àíòîëîãèÿ íàó÷íûõ ïóáëèêàöèé
