ÍÅÑÏÅÖÈÔÈ×ÅÑÊÀß ÈÌÌÓÍÎÒÅÐÀÏÈß
ÊÀÊ ÑÐÅÄÑÒÂÎ ÇÀÌÅÄËÅÍÈß ÑÊÎÐÎÑÒÈ
ÌÅÒÀÑÒÀÇÈÐÎÂÀÍÈß Ó ÁÎËÜÍÛÕ
ÓÂÅÀËÜÍÎÉ ÌÅËÀÍÎÌÎÉ
A.A. Eeoaaioaaa, I.I. Nie?iia, I.A. Eaoyaeia
IIEE AA ei. Aaeuiaieuoa, Iineaa,
OII «Aeioao», N.-Iaoa?ao?a, ?inney
Ioa?anoaaiiua oeoieeiiaua i?aia?aou iaoiayo ana aieaa
oe?ieia i?eiaiaiea a iieieiae?aneie i?aeoeea. Aaiiua ia yo-
oaeoeaiinoe eniieuciaaiey eiioiiei??aeoi?ia oeoieeiiaiai
?yaa i?e ?acee?iuo iiooieyo i?ioeai?a?eau, a i?e oaaaeuiie
iaeaiiia, ioiinyuaeny e ?ac?yao ??acau?aeii ceiea?anoaai-
iuo, oeiei?acenoaioiuo iiooieae, a ainooiiie eeoa?aoo?a io-
noonoao?o.
Oaeu? iaoae ?aaiou yaeeinu i?iaaaaiea aiaeeca eeeie?a-
neie e eiioiiei??aeoe?o?uae yooaeoeaiinoe EE-2 (?iieieae-
eeia) o iaoeaioia n aaia?aeeciaaiiie noaaeae oaaaeuiie iaea-
iiiu.
Iia iaae?aaieai iaoiaeeinu 11 iaoeaioia n aaia?aeeciaai-
iie noaaeae oaaaeuiie iaeaiiiu (T3-4N0Mhep) I?e iinoaiiaea
aeaaiica e ioaiea eeeie?aneiai ?acoeuoaoa eniieuciaaee aai-
iua eino?oiaioaeuiuo enneaaiaaiee (?aioaaiieiae?aneiai,
oeuo?acaoeiaiai, ?aaeiecioiiiiai eee eiiiu?oa?iie oiiia?a-
oee). O 7 ?aeiaae iaoanoace?iaaiea ianooieei a n?iee io 6 ia-
nyoaa ai 5 eao iinea yioeeaaoee. A o?ao neo?ayo yioeeaaoe?
i?iecaiaeee a nayce n aieyuae aoi?e?iie aeaoeiiie ia oiia
eia?ueony iaoanoacia. O iaiiai iaoeaioa aennaieiaoey i?i-
ecioea i?e iaee?ee inoaoi?iie iiooiee nionoy 2 aiaa iinea a?a-
oeoa?aiee.
Eiioiieiae?aneee iiieoi?eia, aee??a?uee enneaaiaaiea
eiee?anoaaiiuo e ooieoeiiaeuiuo iieacaoaeae O-, A-eeioioe-
oia, IK-eeaoie, iaeo?ioeeia, eioa?oa?iiiaiai noaoona, i?iaoe-
oee oeoieeiia, inouanoaeyee iaeaioia e nionoy 5-7 aiae iinea
ea?aiey. ?iieieaeeei aaiaeee ?a?ac aaiu ii 1 iei aa. aioo?e-
aaiii, eaiaeuii ¹ 5. I?iecaiaeeanu eioaa?aeuiay ioaiea yo-
oaeoeaiinoe i?aia?aoa n eniieuciaaieai eiaaena aaoeoeoa O-
nenoaiu. Ioia?aee oaaee?aiea eiee?anoaa CD3+, CD4+, CD8+,
CD16+ (?<0,02) e eo ooieoeiiaeuiie aeoeaiinoe. Iiauoaeanu
?anoioa auyaeaiey e o?iaaiu i?iaoeoee OII-a, EE-8, i?eaee-
?aynu e aiii?neei cia?aieyi. Oiaiuoaeanu eiioaio?aoey EE-
2Rs. Ia eciaiyeenu o?iaie EE-1b, AI-KNO, eioa?oa?iiii?i-
aoeoey.
Keeie?aneee yooaeo au?a?aeny a oeo?oaiee iauaai ninoiy-
iey aieuiiai (ono?aiaiea eaioa?i-annioee?iaaiiie o?iie?an-
eie ooiieyaiinoe, ii?iaeecaoee nia, aiiaoeoa, iano?iaiey,
ainnoaiiaeaiey aeoeaiiai ia?aca ?ecie), eioi?ia ianooiaei ii
caaa?oaiee eo?na eiioiiei??aeoee. Oeo?oaeinu eo ea?anoai
?ecie. Yioeeaaoey, i?iaiaeiay ia oiia aaaaaiey ?iieieaeee-
ia, ia i?iaioe?iaaea i?ia?anne?iaaiea iaoanoace?iaaiey. Io-
ia?aee noaaeeecaoe? i?ioanna o 9 iaoeaioia (a n?iee iaae?aa-
iey 6-18 ian). Iiaoi?y?ueany ?a?ac 3 ian eo?nu aaee aiiieie-
oaeuiue yooaeo a aeaa oiaiuoaiey ?acia?ia iaoanoacia a ia-
?aie ia 30% (n=1). A 1 neo?aa ea?aiea ieacaeinu iayooaeoea-
iui; aieuiie oia? io aaia?aeecaoee i?ioanna. I?iaie?eoaeu-
iinou ?ecie ninoaaeea 18 ian n iiiaioa iiyaeaiey iaoanoacia
e ia?aea ea?aiey.
Nouanoaaiiuo inei?iaiee i?e i?iaaaaiee eiioiiei??ae-
oee ?iieieaeeeiii, ca enee??aieai oia?aiiie e?aoeia?a-
iaiiie aeia?oa?iee e a?eiiiiiaiaiie eiiiou a einoyo, ia ia-
ae?aaee.
Oaeei ia?acii, eiioiiei??aeoey n eniieuciaaieai eo?nia
?iieieaeeeia o iaoeaioia n oaaaeuiie iaeaiiiie a noaaee aa-
ia?aeecaoee niinianoaiaaea noaaeeecaoee i?ioanna a 91,9%
i?e n?ieao iaae?aaiey 3-18 ian e ieacaeanu iayooaeoeaiie o
9,1% aieuiuo.
IV Eiioa?aioey «Iaeeeaoeaiay iiiiuu a iieieiaee», ai?aey, 1999,
Iaeeeaoeaiay iaaeoeia e ?aaaeeeoaoey, 1999, ¹ 2, no?. 56-57.
ÂÇÃËßÄ ÀÌÁÓËÀÒÎÐÍÎÃÎ
ÕÈÌÈÎÒÅÐÀÏÅÂÒÀ ÍÀ ÀÍÒÈÝÌÅÒÈKÈ
I.A. Iaua?yeiaa, I.I. Aaeaae
Iieieiae?aneee aeniaina? ¹2, Iineaa, ?inney
Oe?ieia eniieuciaaiea oeieioa?aiee a aiaoeaoi?iuo on-
eiaeyo i?aauyaeyao iniaua, ioee?iua io noaoeiia?iuo, o?aai-
aaiey e aioeyiaoeeai. Kiio?ieu ino?ie ?aiou ainoeaaaony e?-
aui aeieaoi?ii NIC-?aoaioi?ia i?aeoe?anee o anao aieuiuo,
?oi ia iaae?aaai i?e ion?i?aiiie ?aioa. Iieeaay aiaaiie
noaoeiia?, aieuiie inoaaony iaei ia iaei n inei?iaieyie ea-
?aiey, naiui oyainoiui ec eioi?uo yaeyaony ?aioa. A?aiy
aaenoaey cio?aia e eao?aia ia?aie?aii 6-8 ?, oiaaa eae iaai-
aaia — ai 24 ?. Aieuiiio, iaoiayuaiony a aiaaiii noaoeiia-
?a, iinea a?aiaiiiai i?iia?ooea ii?ii i?aaei?eou iiaoi?-
iia aaaaaiea oiai ?a cio?aia, ii ninoiyiea ia?eoa?e?aneeo
aai, ?anoe?ii iaeeoa?e?iaaiiuo, iaee?ea iineaiia?aoeiiiiai
eeioinoaca aa?oieo eiia?iinoae ca?anoo? aaeaao i?ioaao?o
aioo?eaaiiiai aaaaaiey io?eoaeuiie eae aey iaoeaioa, oae e
aey ia?niiaea. Iiyoiio, ianiio?y ia aunieo? noieiinou ia-
aiaaia, aey aiaoeaoi?iiai ea?aiey i?aaii?oeoaeuii aai en-
iieuciaaiea — iaiie?aoiia aioo?eaaiiia aaaaaiea n iinea-
ao?uei i?eaiii eainoe ia neaao?uea nooee. ?acoiaaony ia-
iaoiaeii o?eouaaou noaiaiu yiaoiaaiiinoe oeieii?aia?aoia.
I?e ea?aiee iaaaeuaeiii, aaica?ii, iooaieoeiii, oiioaae-
nii aiieia ainoaoi?ii i?aaaa?eoaeuiiai aioo?eaaiiiai aaa-
aaiey cio?aia 8 ia n iineaao?uei i?eaiii oaaeaoie eao?aia
ea?aua 6-8 ?. Oiaaa eae eiiaeiaoee n aio?aoeeeeiaie, aio?a-
oaiaeiiii, ieaoeiiauie i?iecaiaiuie o?aao?o aaaaaiey
?anoai?a iaaiaaia e i?eaia eainoe a oa?aiea ianeieueeo
aiae. I?e ea?aiee oaenaiaie, ooi?o?aoeeii aioeyiaoeee i?a-
eoe?anee ia o?aao?ony.
Iaie ioia?aia oae?a i?yiay caaeneiinou ia?ao ineoiyii-
oeiiaeuiui ninoiyieai aieuiuo, o?iaiai eo eioaeeaeooaeuii-
ai ?acaeoey, inaaaiieaiiinou? i ?acee?iuo aioeyiaoeeao e ?a-
noioie aicieeiiaaiey yieciaia ?aiou. Iieo?ay iaaiaai, oaeea
iaoeaioee ?oanoao?o naay aieaa caueuaiiuie, o ieo nieiaaony
yooaeo «i?eaaiey ?aiou», e yiaoiaaiiua inei?iaiey i?aeoe-
?anee ia aicieea?o. Kiio?ieu ino?ie e iicaiae ?aiou nio?aiy-
aony a yoeo neo?ayo e i?e iiaoi?iuo eo?nao.
IV Eiioa?aioey «Iaeeeaoeaiay iiiiuu a iieieiaee», ai?aey, 1999,
Iaeeeaoeaiay iaaeoeia e ?aaaeeeoaoey, 1999, ¹ 2, no?. 62.
ÍÅÑÒÅÐÎÈÄÍÛÅ
ÏÐÎÒÈÂÎÂÎÑÏÀËÈÒÅËÜÍÛÅ ÏÐÅÏÀÐÀÒÛ
 ËÅ×ÅÍÈÈ ÕÐÎÍÈ×ÅÑKÎÉ ÁÎËÈ
Ó ÁÎËÜÍÛÕ Ñ ÐÀÑÏÐÎÑÒÐÀÍÅÍÍÛÌÈ
ÔÎÐÌÀÌÈ ÇËÎKÀ×ÅÑÒÂÅÍÍÛÕ
ÍÎÂÎÎÁÐÀÇÎÂÀÍÈÉ
A.A. Iiaeeia, I.A. Aaeniai, A.I. I?ioi?ia, N.A. ?oaie,
E.E. Aaiainii, I.A. Aaaaieia
Iineianeee iao?ii-enneaaiaaoaeuneee einoeooo
ei. I.A.Aa?oaia,
Kaoaa?a iieieiaee n eo?nii iaeeeaoeaiie iiiiue OIII
IIA ei. E.I.Na?aiiaa,
AKA N 11, Iineaa, ?inney
Ianoa?ieaiua i?ioeaiainiaeeoaeuiua i?aia?aou (IIAI)
oe?iei i?eiaiy?ony a ea?aiee o?iie?aneie aiee (OA) ?acee?-
iiai aaiaca, a oii ?enea o iieieiae?aneeo aieuiuo. Iaoaieci
aaenoaey IIAI naycai n oaiaoaieai aeoeaiinoe oeeeiieneaaia-
cu — oa?iaioa, ioaaonoaaiiiai ca neioac i?inoaaeaiaeiia, nai-
neaeeece?o?ueo iioeoaioi?u. Ecaanoii, ?oi IIAI, eiio?iee-
?oy i?ioannu ia?aaa?e e aini?eyoey aieaauo eiioeunia, iaan-
ia?eaa?o aiaeuaaoe?aneee yooaeo. A ianoiyuaa a?aiy caneo?e-
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